Successful epileptic pregnancy after the alteration of the regimen of anticonvulsants.

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Life-threatening neonatal hemorrhage is associated with maternal anticonvulsants, such as phenytoin, phenobarbital and primidone. We experienced a neonate born from a epileptic mother treated with phenytoin and phenobarbital, who died at 25 hours after birth from profuse intraabdominal hemorrhage resulting from ruptured subcapsular hematoma of the liver. After the pregnancy, the regimen of anticonvulsants was altered from phenytoin and phenobarbital to valproate sodium alone. She became pregnant again and delivered a healthy neonate uneventfully.<BR>In epileptic women who have encountered hemorrhage or coagulation defect of their offsprings in previous pregnacies, the regimen of anticonvulsants should be altered to other drugs than phenytoin, phenobarbital and primidone, before the next pregnancy.
近畿産科婦人科学会の論文