Studies on the pathogenesis of cancer anemia.

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On the basis of the results of hematological and clinical studies, we learned that most cases of cancer anemia consist of normochromic normocytic anemia. Also, the cause of cancer anemia was not a decrease in hematopoiesis in the bone marrow but an increase in hemolysis in the spleen due to fragility of the erythrocytes.<BR>Anemia-inducing substance (AIS), found in the serum of cachectic patients, is known to have a detrimental effect on RBCs and shorten the lifespan of RBCs.<BR>The effects of AIS were examined, and the findings can be summarized as follows. (1) The osmotic resistance and the deformability of RBCs were decreased in patients with terminal cancer. (2) Normal human RBCs showed reduced deformability and their membranes became fragile after treatment with cachectic serum from the terminal cancer patients, and those changes in the physical properties of RBCs were irreversible. (3) The energy metabolism of the RBCs was affected by AIS, that is, the ATP concentration and pyruvate kinase activity in the RBCs were lowered and the trans-membrane glucose influx was suppressed. These observations strongly suggest that AIS appears in the blood of patients with terminal cancer, causes impairment of RBCs and plays a role in the pathogenesis of cancer anemia.
近畿産科婦人科学会の論文