The Thomsen-Friedenreich antigen in uterine cervical cancer tissue and culture cells, and thier alteration by drugs.
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We studied the Thomsen-Friedenreich (T) antigen in uterine cervical cancer tissues and cell lines, and their changes by drugs. We stained tissues and culture cells by way of Abidin-Biotin-peroxidase Complex (ABC) method using a monoclonal antibody to the T antigen. The antibody was obtained by immunizing mouse with asialo-glycophorine. The results were as follows. 16 of 24 (66.7%) tissues were stained positive, and the cell line OMC-1 and OMC-4 were positive in cytoplasms. As the T antigen appeared frequently in uterine cervical cancer tissues and culture cells, we can use the T antigen as the tumor marker for the uterine cervical cancer. The T antigen was not changed so much by 5FU and EGF in OMC-1 and OMC-4 from our study using the Enzyme-Immuno-Assay (EIA). So the T antigen is concerned with modulation of the uterine cervical cancer, but not so much with damages and growth of it.
- 近畿産科婦人科学会の論文
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