Clinical study of 48 ovarian cancer patients.

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This is a retrospective study of 48 patients with ovarian cancer treated at the Shiga University of Medical Science between January 1979 and December 1987. The standard operative procedure was bilateral salpingooophorectomies, abdominal total hysterectomy and partial omentectomy. First line chemotherapy was FAM (T), CAP (F), or QF for epithelial ovarian carcinoma, and VAC or VAQ for germ cell ovarian cancer. Second line chemotherapy after development of the resistance to CAP (F) was PCE or VPP.<BR>The five-year survival rates for primary ovarian cancer were 80.8 % for stage I, 41.1% for stage III, and 22.5 % for stage IV. For the stage I and II primary ovarian cancers, the five-year survival rate was 83.3% with CAP (F) chemotherapy, and 100% with FAM (T). No significant difference was found between CAP (F) and FAM (T). For stage III and IV primary ovarian cancers, the two-year survival rates was 80.0% with CAP (F), and with 0.0% with FAM (T) a significant difference.<BR>In ten patients, a second-look laparotomy/laparoscopy after the standard operation and adjuvant chemotherapy was performed as a part of the management protocol. Six patients with cancer positive results confirmed by a second-look laparotomy/laparoscopy had a median duration of only 6.2 months of remission. One of the six patients died, and three patients had recurrent tumors. Four patients with cancer negative results confirmed by second-look laparotomy/laparoscopy had a median duration of 24 months of remission. All four patients are alive and show no evidence of disease.<BR>In all cases of recurrent or uncontrolled tumors after first line chemotherapy, There was no or very poor response to second line chemotherapy.<BR>The treatment of stage I and II ovarian cancer and acquired drug resistance to first line chemotherapy must be leaved for a future study.
近畿産科婦人科学会の論文

Clinical study of 48 ovarian cancer patients.

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近畿産科婦人科学会 | 論文

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