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The combined therapies such as CO2 laser evaporation, local radiation and continuous arterial infusion of anti-carcinogenic drugs were performed against the patient with metastatic vagianl carcinoma derived from rectal cancer, from years after the radicalr esection, and the remarkable regression of tumor growth was observed. This patient was found to have the ulcer near fornix of vagina with high serum value of CEA (10.7ng/ml). The cytology test by contact smear and biopsy of the ulcer proved that this ulcer was adenocarcinoma derived from the previous rectal cancer. After admission to the hospital, the patient was treated by combined therapies as local injections of OK-432, extended CO2 laser evaporation to the ulcer and local radiation by 60CO (total 4, 700 rads) and the continuous infusions in reginal artery (Lt-internal iliac artery) with 250 mg of 5 FU per day for 20 days and 100mg of ACNU per week for 2 weeks were applied, because the serum value of CEA did not drop even after therapies, and the tumor invasion was found to localize deep under the vaginal wall by CT. After this therapy, the serum value of CEA and the size of ulcerative carcinoma in vagina were strikingly decreased with necrotizing dermatitis as the major side effect. The other cosiderable side effects due to drug toxicity and arterial infusion were not demonstrated.
近畿産科婦人科学会の論文