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Increased rate of perinatal complications including low birth weights and prematurity, and arize in the perinatal mortality rate has been reported in the smoking pregnant women. Decreased uterine blood flow which is induced by nicotine would appear to be important for the deleterious effect of maternal smoking on fetal well-being. In order to elucidate the mechanism of the contractile responsiveness to nicotine of uterine vascular bed, the isometric tension responses of spiral strips of sow uterine arteries to nicotine or norepinephrine (NE) were measured using in vitro technique. The effect of α-adrenergic blocking agent phentolamine on these tension responses was also studied and the role of sympathetic α-receptor in the response to nicotine of pregnant sow uterine artery was discussed. The preparations of arterial strips were mounted in organ bath with Krebs-Henseleit solution maintained at 37° and continuously bubbled with a gas mixture of 5% CO2 in O2. The tension signal was electrically integrated and recorded on a rectigraph under 1g weight basement tonus. Four doses of nicotine (final concentration of 10-7-10-4M) and 5 doses of NE(0.05-1.0μg/ml) were added into the buffer solution and the increases in tension were measured at each plataux value. The effects of phentolamine (10-7-10-6g/ml) on the nicotine-induced contractions, and the effects of nicotine (10-7-10-6M) on norepinephrineinduced contractions were also examined in nonpregnant preparations.The results were as follows;1) Contractile responses (ΔT) of uterine arterial strips from late pregnant sows to nicotine were significantly smaller than those of nonpregnant control (24.1% of control at 10-4 M nicotine concentration), while responses of preparations from the sow in early stage of pregnancy were comparable to the control.2) In the nonpregnant preparations, blockade of α-adrenergic receptor by 10-7-10-6g/ml phentolamine eliminated significant amount of vascular contractility to nicotine in a dose dependent fashion.3) NE increased the ΔT dose-dependently in a similar manner to that of nicotine administration, but the responses of the preparations of late stage of pregnancy were greater than that of nonpregnant or early pregnant preparations.4) NE-induced ΔT of preparations from both late pregnant and nonpregnant animals
- 近畿産科婦人科学会の論文
近畿産科婦人科学会 | 論文
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