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Sulpiride, a non-hormonal agent which induces hyperprolactinemia, is therapeutically effective in endometriosis since a secondary effect of the drug is anovulation or amenorrhea. We used sulpiride in the treatment on 15 female patients with endometriosis consisting of 7 who had conservative operation for endometriosis, 5 diagnosed as having endometriosis by physical examinations and laparoscopic findings or HSG, 2 with recurrent endometriosis after pseudopregnant therapy and 1 with hepatitis during pseudopregnant therapy.These patients were administered sulpiride in doses of 100 to 300mg/day for 90 to 200 days. Ten patients (66.7%) had amenorrhea and 12 (80%) had anovulatory cycle. In these patients, serum PRL concentration increased immediately after dosing and were maintained at about 200ng/ml, regardless of dose and duration. Serum gonadotropin levels were 10 to 20mIU/ml and LH surge was suppressed. Serum estradiol levels were as low as 45.2±16.9(±SD)pg/ml, i. e. similar to values in the early follicular phase and progesterone values were as low as 2.73±2.20pg/ml which confirms that they had anovulation. Of the 13 patients with dysmenorrhea, 10 (76, 9%) improved markedly and 1 of the 14 patients became pregnant after this treatment.These findings suggest that sulpiride is useful for the treatment of endomentriosis but theaction of the drug on endometriosis is due to hyperprolactinemia which causes anovulation or amenorrhea. The effect is assumed to be reversible.
- 近畿産科婦人科学会の論文
近畿産科婦人科学会 | 論文
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