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This paper concerns to the data on the cyclic use of SC-11800EE as an oral contraceptives in 66 healthy women for a total of 1, 034 cycles. SC-11800EE is a mixture pill of 0.5mg of ethynodiol diacetate and 0.05 mg of 17α-ethinyl estradiol. In the first treated cycle, the pill was administered 1 tablet daily for 21 days, beginning from the 5th day of the cycle. After waiting 7 days the 21-day course was started again on the same day of the week, regardless of whether menstruation had occurred in the interim or was still in progress. This schedule of administration was repeated for each of the cycles.There has been no pregnancy in this study. The cycle length in the treated cycles was markedly stabilized as composed with that in the untreated cycles, and 83.4% of all cycles were 27 to 29 days long. An average cycle length was 28.0±1.2 days with the administration. Withdrawal bleeding occurred 2 to 4 days after the last administration in 88.6% of the treated cycles. Duration and quantity of menstrual flow underwent a definite deminition compared with those of untreated cycles. In 79.0% of all cycles, withdrawal bleeding was of 3 to 4 days duration. Spotting and breakthrough bleeding occurred in a total of 62 cycles (6.0% of all cycles). Amenorrhea was observed in 2.6% of 1, 034 treated cycles. Side effects usually encountered with drugs of this type, are nausea and vomiting and they are the most troublesome. Nausea and vomiting under the administration of this pill occurred in 2.7% of all cycles and greater in the early 3 cycles, but gradually decreased with the continuance. Other side effects observed were discharge increase, headache and abdominal pains, but the latter two occurred infrequently. Weight gain was observed in 6.1% of all patients. Liverfunction tests were carried out at regular intervals. Abnormal values were observed in following examinations, GOT in 9.1%, GPT in 4.5%, and TTT in 6.1%. The incidence of the abnormality returned to normal during or after the discontinuance of the medication. In this study, there did not occur hypertension in any case. Jaundice and thrombophlebites were not observed.There was no significant impairment of conception in long-term users as compared with short-term users in the post treatment of this contraceptive pill. Although pregnancy occurred rapidly when the cyclic use of this contraceptives was discontinued, it should be noted that the first post-treatment cycle tend to be prolonged, although in some women it might be shortened. In two patients the flow of the first cycle was heavy and prolonged, but the bleeding subsided spontaneously and subsequent menses were normal. In conclusion, this combination regime may be considered convenient and useful for the purpose of contraception.
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