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Four cases of ovarian clear cell carcinoma were studied ultrastructurally and histochemically in comparison with normal endometria (10 cases), endometria in pregnancy (8 cases) and endometrial adenocarcinoma in various degree of differentiation (20 cases).CEA staining was carried out by immunoperoxidase technique in one case. Clear cell carcinomas examined consisted predominantly of a compact arrangement of large pleomorphic cancer cells with hyperchromatic, indented often lobulated nuclei. The hobnail cells had bulging nuclei into the lumens of tubules. The lumens of the tubules contained moderate electron dense substances which revealed positive reaction with PAS staining. In narrow intercellular spaces, there was an accumulation of basement membrane-like materials. The cytoplasm of the neoplastic cells was characterized by a massive aggregates of glycogen depositions and a parallel array of rough endoplasmic reticulum. Moreover numerous lipid droplets often associated with glycogen depositions and lysosome-like dense granules were observed. From the morphological viewpoint, the clear cell carcinoma of the ovary revealed several resemblances with the fine structures of secretory or hypersecretory (Arias-Stella type) endometria with emphasis on the presence of cytoplasmic glycogen and the arrangement of rough endoplasmic reticuli but not to endometrial adenocarcinoma. Moreover, two cases out of four disclosed the co-existence of pelvic endometriosis. By CEA staining, a small number of neoplastic cells revealed intense positive reaction on the cytoplasmic membrane and faintly positive reaction in their cytoplasm. From the results obtained, it is suggested that the clear cell carcinoma may be an expression of endometrioid carcinoma with secretory manifestations. On the basis of the facts described and the available histologic evidence, the histogenesis of the ovarian clear cell carcinoma has been discussed referring the reports dealing with related problems.
- 近畿産科婦人科学会の論文
近畿産科婦人科学会 | 論文
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