Successive Measurement of Cell-Mediated Immunity in Predicting the Malignant Changes of Hydatidiform Mole

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In order to find out a reliable marker for predicting malignant of hydatidiform mole, changes of hCG titer in urine and cell-mediated immunity were monitored in 10 molar patients before and after the evacuation.In the present study, 4 out of 10 patients were diagnosed as successively malignant trophoblastic disease at least 4 weeks or more after the evacuation on the basis of high urinary hCG level and following PAG.Between successive and non successive trophoblastic disease, a significant difference was found in the response of DNA synthesies of peripheral lymphocytes to PHA measured by the micro whole blood culture method.On the other hand, sera obtained from the patients with successive change suppressed more significantly the DNA synthesies of healthy volunteer's lymphocyte than sera from the patients without successive change.This immunosuppressive effect was already observed even at the state of mole in utero.The results might suggest the immunosuppressive effect of sera could discriminate successive changes of hydatidiform mole markedly faster than hCG titer, hence a newer and reliable method for predicting a prognosis of the molar pregnancy was proposed.
近畿産科婦人科学会の論文