The Effect of Prostaglandin F2α and other Vasoconstrictor Substances on Uterine and Renal Blood Flow in the Nonpregnant Dog
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1) The effects of prostaglandin F2α(PGF2α), which increases in the late pregnant blood, on the vasomotor responses of noradrenaline and angiotensin II were tested in the kidneys and the uteruses of nonpregnant dogs. The renal and uterine artery blood flows were measured by square-wave electromagnetic flowmeters and the arterial blood pressure was measured by pressure transducer. These flow signals and pressures were electronically integrated and displayed simultaneously on a pen recorder.2) When the effective doses of PGF2α were injected intravenously, blood pressure increased and was accompanied by a decrease in uterine blood flow (UBF) ;however, renal blood flow (RBF) scarcely changed. This decrease in UBF seems to be due to contraction of the uterine vessels, as indicated by the lack of periodicity in UBF.3) After the injection of noradrenaline, a remarkable decrease occurred RBF and UBF, along with a simultaneous rise in blood pressure. These responses did not change even after the PGF2a injection. From these facts, it is assumed that PGF2α acts on another site besides the α-receptor of the vessel wall.4) After the injection of angiotensin II, RBF decreased rapidly;however, UBF increased, accompanied by an increase in blood pressure. We cannot help thinking that this increase of UBF depends upon the organ specific reaction of vessels, based upon the usual vasoconstrictive effects of angiotensin.5) Injection of effective doses of PGF2α inhibited the responses which followed the administration of angiotensin II. The decrease in RBF and the increases in blood pressure and UBF which followed the injection of angiotensin II were all mitigated after the PGF2α injection. That is to say, taking as 100% the response which followed the administration of angiotensin II 1.0μg alone, the decrease in RBF and increases in UBF and blood pressure were limited to 64%, 30% and 35% respectively.6) The inhibitory effect of PGF2α on the responses to angiotensin II shows a pattern of maintaining the RBF by means of reducing the UBF. Since PGF2α and angiotensin II increase their concentration n the blood during the late stage of pregnancy, these antagonistic effects of these two substances seem to act as a regulator of the visceral and corporal circulation during pregnancy.
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