Clinical Study on Gonadotropin Reserve Function of the Anterior Pituitary Gland
スポンサーリンク
概要
- 論文の詳細を見る
The synthetic luteinizing hormone releasing factor (LRF) was injected intravenously in a dose of 200μg to test the gonadotropin reserve function of the anterior pituitary to respond to LRF with a release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) in 21 healthy regularly menstruating women, 24 anovulatory patients, 14 pregnant women and 20 puerperal women. Venous blood was obtained at 0, 15, 30, 45, 60, 120, minutes after LRF injection and assayed for LH and FSH by double antibody radioimmunoassay (RIA).All the women with normal menstrual cycles responded to LRF with a significant increase of LH and FSH, and a more positive pituitary responsiveness to LRF was observed in the preovulatory phase compared with that seen in the other phases of menstrual cycle.Anovulatory patients with estrogenic activity responded to LRF with approximately the same increase of LH and FSH as the women in the early follicular phase or luteal phase.Anovulatory patients without estrogenic activity were classified in the following 3 groups by the endoclinological examination; primary (ovarian), secondary (pituitary) and tertiary (hypothalamic) hypogonadism. The response patterns of LH and FSH of the 3 groups were very different.In the patients with primary hypogonadism, a greater pituitary responsiveness to LRF was observed than that seen in the other two groups.In the patients with secondary hypogonadism, basal LH and FSH levels were very low and were unchanged after LRF injection.In the patients with tertiary hypogonadism, the same degree of pituitary responsiveness to LRF as the early follicular phase or luteal phase was observed, but it was less than that seen in the patients with primary hypogonadism.From these results, it might be concluded that, the LRF test should be useful for the differential diagnosis of the lesion of anovulation as well as for the test of reserve function of the anterior pituitary in anovulatory patients.In pregnant women, the basal levels of LH and FSH were very low and no pituitary response was observed, so it might be concluded that gonadotropic function of the anterior pituitary is suppressed by an unknown mechanism during pregnancy.As for puerperal women, the basal LH and FSH levels were very low and no responsiveness of the anterior pituitary to LRF was observed in the 1st week puerperal women, but after that the pituitary responsiveness to LRF gradually returned to normal. These results indicate that the gonadotropic func tion of the pituitary gland is suppressed by residual gonadal steroids or HCG during the first few postpartum weeks, but response to LRF recovers gradually with a disappearance of these hormones. Moreover, it might be concluded that puerperal anovulation and amenorrhea is due to hypothalamic-pituitary dysfunction during the first few weeks of puerperium and due to hypothalamic disorders after the 5th postpartum week
- 近畿産科婦人科学会の論文
近畿産科婦人科学会 | 論文
- 当院における卵巣粘液性腺癌の治療経験の検討
- 婦人科癌末期の難治性イレウスに対する減圧目的の経皮的内視鏡的胃瘻造設について
- 子宮体癌の保存的治療後妊娠での前置癒着胎盤に対し内腸骨動脈バルーン留置下で帝王切開および子宮全摘術を施行した1例
- 当科の卵巣粘液性腺癌の治療成績 : ─リンパ節郭清の適応についての考察
- 妊娠糖尿病を合併した高度肥満妊婦の分娩誘発の1例