Effects of a Intraperitoneally Administered Antibiotic (Vistamycin) on the Ultrastructure of the Peritoneal Mesothelial Cell Surface of Mice:Scanning Electron Microscopic Study
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The intraperitoneal infection is a grave complication of the abdominal surgery for infected female sexual organs, but, the incidence and intensity have remarkably decreased by the development of antibiotics. However, massive dosages or random administration of the antibiotics resulted in some adverse effects. Especially, the direct administration of them into the abdominal cavity, for expecting high local concentration in the infected focus, resulted in unfavorable and fatal complications, particularly intraperitoneal adhesions.We previously reported ultrastructural changes of peritoneal mesothelial cells of mice to foreign bodies, —hen's bile and colloidal silica (Advances in Obstetrics and Gynecology; 28, 205-217, 1976).In this study, changes of peritoneal mesothelial cells to the 5%, 25% and 50% solution of the antibiotic (Vistamycin) administered into the peritoneal cavity of mice were observed by a scanning electron microscope.There were no macroscopic peritoneal adhesions in each experimental groups.Ultrastructure of the surface of mesothelial cells did not show any changes with 5% Vistamycin solution, but with solutions of higher concentration, the surface of mesothelial cells showed some changes, especially, of microvilli which were deformed, shortened and partially disappeared.It is concluded that the Vistamycin solution of higher concentration, intraperitoneally administered, injures mesothelial cells, possibly to make peritoneal adhesions, but the 5% solution may be used intraperitoneally without severe side effects.
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