Change of Cellular Immune Status in Pregnant Individuals
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概要
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From the point of view of transplantation immunity a successful intrauterine graft of genetically alien participants could never be explained without a peculiar mechanism in the usual mammals. This study was attempted to make the maternal cell-mediated immune status clear by the modified micro whole blood culture to phytohemagglutinin (PHA) technique and further by the microplate technique.1) Change of maternal lymphocyte reactivity during the gestational period.The lymphocyte reactivity to PHA in 150 pregnant subjects had a peculiar alteration in their response;significant elevation in the third trimester specially in the last gestational month in contrast with predominant reduction in the first trimester and gradual increase until lower limit of normal range in the second trimester.2) Change of lymphocyte-subpopulation (T-cell, B-cell) during the gestational period.The count of thymus derived lymphocyte (T-cell) per a unit blood volume which is responsible for cell-mediated immunity as a immunocompetent cell was similar to the pattern of PHAinduced lymphocyte reactivity as descrived above.On the contrary, B-cell count showed to be inverse proportion with T-cell count.It was concluded that pregnant individuals were maintained under the immunologically adaptive status and this characteristic alteration of maternal cell-mediated immunity referred to the change of lymphocyte-subpopulation such as T-cell and B-cell.Such a rational change of maternal immune status seems to be prerequisite to the maintenance and immunological rejection (trigger factor of labor) of the fetus and its appendix.
- 近畿産科婦人科学会の論文
近畿産科婦人科学会 | 論文
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