Induction of Labor by Prostaglandin F2α

概要

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Continuous drip infusion of prostaglandin F2α was performed in 28 cases ranging from 39 to 42 weeks of gestation. Labor was successfully induced in all cases, and in 22 cases delivery was terminated during the treatment. The success rate was 78.6%. Success to delivery was greatly influenced by the selection of patients, i. e. parity and Bishop score of each case. Multiparas with large Bishop score had higher success rate than primiparas with smaller Bishop score. In addition to the appropriate doses and infusion speed of the medicine, the selection of patients with the socalled "Mature Uterine Cervix" is necessary to attain high success rate.The side effects are uterine hypertonus, nausea, vomitting, diarrhea, and others, and some 40% of all cases had some of these complications. In 6 cases infusion had to be suspended during the treatment because of these complications. There seems to be close correlation between the uterine and intestinal effects of prostaglandin F2α with regards to the infusion doses. Significant leucocytosis was noted in several cases, but no other apparent effects were revealed in the maternal laboratory values. No significant effects were seen on the newborn infants.
近畿産科婦人科学会の論文