The estimation of urinary LH and HCG excretion by Luteonosticon and the comparison with the serum level estimated by radioimmunoassay
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In this study a modified haemagglutination inhibition test for the estimation of LH and HCG in urine by using Luteonosticon is described. The daily early morning levels of urinary LH were estimated by Luteonosticon in 7 women with normal menstrual cycles and 5 patients with anovulatory cycles. Urinary HCG levels in 9 patients with chorionic tumor were also determined by Luteonosticon. These results were compared with serum levels of LH and HCG in corresponding time estimated by sensitive and specific double antibody radioimmunoassay. The sensitivity was 25IU/L in LH and 10IU/L in HCG.The general pattern of daily urinary LH during normal menstrual cycle ran parallel with the pattern of daily serum LH levels previously reported by us. At midcycle, urinary LH had a peak lasting about 2 days which was seen 1 to 2 days after the serum LH peak. During follicular and luteal phases the base line of LH excretion were 25 to 50IU/L but random surges up to 100 to 200IU/L without the surge of serum LH were obtained in some cases. Pattern of LH excretion during anovulatory cycle generally agree with that of serum LH.The estimatipn of urinary HCG under the concentration of 1000IU/L were performed in 9 patients with chorionic tumor after chemotherapy with methotrexate and actinomycin D. The declining curves of HCG excretion ranged between 160 to 10IU/L correlated very much with the transition of serum HCG. The levels of HCG excretion were always below 80IU/L when the level of serum HCG showed below 50IU/L.In conclusion, as Luteonosticon is easy to handle and sensitive enough to measure urinary levels of both LH and low titer HCG, its clinical application to the infertility clinic and the management of chorionic tumor are recommended.
- 近畿産科婦人科学会の論文
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