Resuscitation with Low Molecular Weight Hydroxyethyl Starch Solution for Experimentally Induced Hemorrhagic Shock in Dogs.

概要

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The aim of this study was to investigate the efficacy and safety of hydroxyethyl starch solution (HES), a low molecular weight synthetic colloid, in the resuscitation of experimentally induced hemorrhagic shock in dogs. Hemorrhagic shock was experimentally induced in 12 beagles by blood letting over 5min, and the blood pressure was maintained stable at 40mmHg for 30min. Six of the dogs were then reinfused with 20ml/kg HES over 5min. The remaining 6 dogs were infused with 60 ml/kg lactated Ringer's solution over 5 min. Changes in parameters in systemic hemodynamics, blood gases, complete blood count, serum chemical profiles, coagulation status and urinalyses were compared between the groups. After resuscitation of hemorrhagic shock, the systemic hemodynamics were restored and maintained in dogs treated with low molecular weight HES. At the dosage used, no side effects were observed. It was suggested that low molecular weight HES can efficaciously and safely be used for the acute resuscitation of hemorrhagic shock in dogs.
獣医麻酔外科学会の論文