The Effects of Actmin as an Immunoactivator against the Suppression of Lymphoproliferation after Anesthesia and Surgery in Dogs.
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The <I>in vitro</I> and <I>in vivo</I> effects of Actmin<SUP>®</SUP> (immunoactivator) on the prevention of immunosuppression by anesthesia and surgery were studied in dogs. In <I>in vitro</I> studies, peripheral blood lymphocytes (PBL) were obtained from 16 dogs. PBL in group II (halothane treated group) were exposed to halothane for 20 minutes, whereas those in group I (halothane untreated group) were not exposed. Actmin, concanavalin A (Con A), or interleukin-2 (IL-2) was directly added to the PBL of both groups to compare the immunoactivation effect. In <I>in vivo</I> studies, the preventive effects on immunosuppression after surgery were evaluated through changes in lymphoproliferative responses by Con A, phytohemagglutinin-P (PHA), and lipopolysaccaride (LPS) using 10 clinical cases. They were divided into the following two groups after surgery under general anesthesia. Five dogs in group B were administered Actmin (0.2 ml/kg, b.i.d.) orally after surgery for nine days. Five dogs in group A were not administered Actmin. Proliferative responses of group II were lower than those of group I at 3 day culture under the addition of Actmin. These responses of Actmin-added group were higher to those of Con A or IL-2-added group at 3 and 7 day culture. The stimulation index of Actmin-added group at 7 day culture was higher than that of the same group at 3 day culture. <I>In vivo</I>, significant suppression in lympho-proliferation was observed after surgery in Actmin-unadded group. On the contrary, dogs that received oral administration of Actmin gave nonsuppressive proliferation to mitogen after surgery. These results suggest that Actmin produces higher immunoactivation compared with Con A and IL-2 and prevents immunosuppression after anesthesia and surgery in dogs.
- 獣医麻酔外科学会の論文
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