Possible adverse effects of phenytoin given transplacentally on the fetal growth. II. Possible adverse effects on the fetal growth.:II. Possible Adverse Effects on the Fetal Growth

概要

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This study was undertaken to examine the transplacental transmission of phenytoin and its possible adverse effects on the fetal growth. When pregnant mice were fed with the chow containing various doses of PHT from 14 days before mating until the 18th day of gestation and then they were sacrificed, PHT concentrations in the fetal brain, liver, kidney and amniotic fluid increased steadily with each increment of mate rnal serum concentration and correlated well with maternal serum PHT. The abortion ratein the experimental groups increased steadily with each increment of PHT dosage. The body length, bodyweight, and contents of DNA and RNA in the brain of experimental groups were significantly lower than those in the controls. The incidence of cleft palate increased steadily in the experimental groups with each increment of PHT dosage.
一般社団法人日本小児神経学会の論文