Technological Innovation in Pharmaceuticals-Mainly Focusing on Combinatorial Chemistry.:-Mainly Focusing on Combinatorial Chemistry-

概要

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In recent years, advances in computer technology together with progress in the biological sciences has led to the development of new automated biological assay systems. Although the type and methodology of the assay are large factors in determining the hit rate of active compounds, maximizing the number and diversity of compounds for screening has become a major concern. Hence, the efficient production of diverse chemical libraries has surfaced as a major research topic, and the last few years have seen a revolutionary change in the pharmaceutical world as automated high-throughput organic synthesis techniques have been developed for what has been termed "combinatorial chemistry." In this report, a brief history of the development of combinatorial chemistry will be described.
日本薬学図書館協議会の論文