A Study of Hypertension A Clinical Pharmacodynamic Study of Synthetic Angiotensin II and Synthetic Aldosterone.
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概要
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Renal pressor factor, angiotensin, acts directly on the adrenal cortex to increase the secretion of aldosterone and produce marked electrolyte changes which influence arterial blood pressure. Experiments were performed by intravenous injection of synthetic angiotensin, synthetic aldos-terone in the adrenalectomized dogs and normotensive subjects who took spironolactone to know whether electrolyte changes might be caused directly by angiotensin or by hypersecretion of aldosterone. These results lead to the following conclusion : Synthetic angiotensin I and synthetic aldosterone decreased urine flow and the excretion of Na, Cl. However, the excretion of K was reduced by angiotensin, whereas it was increased by aldosterone. Marked effect of electrolyte excretion was observed in both. Therefore on the one hand the action of electrolyte excretion was done through aldosterone and, on the other hand, it was done directly by angiotensin. Since same effect was observed in the normo-tensive subjects who took spironolactone, it is obvious that angiotensin acts directly on the tubular.
- 社団法人 日本腎臓学会の論文
社団法人 日本腎臓学会 | 論文
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