Potentiation of furosemide by hydrochlorothiazide in chronic renal failure patients.
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概要
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We examined the responses of 8 patients with chronic renal failure (Ccr, 15.4 ± 3.1 ml/min) to oral furosemide (F) (40 mg) in the absence (control) and in the presence of oral hydrochlorothiazide (HCT) (100 mg). In the 24-hour period after oral F, HCT was shown to increase the urine volume, urinary sodium excretion and urinary chloride excretion. The increment was most significant in the 12- to 24-hour period. Enhancement of the diuresis with HCT was associated with neither a significant increase in the area under the curve (AUC) of the plasma F concentration, nor an increase in the urinary F excretion. However, the urinary excretion of glucuronidated furosemide (FG), one of the main metabolites of F, was decreased with HCT. In summary, HCT significantly enhanced the response to F in chronic renal failure patients.
- 社団法人 日本腎臓学会の論文
社団法人 日本腎臓学会 | 論文
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