Renal effects of nifedipine, a calcium antagonist, administered as anti-hypertensive drug.
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Nifedipine, a calcium antagonist, is widely used for the treatment of hypertension, but the renal effects of nif edipine are yet to be investigated. We studied its effects on renal hemodynamics in the patients with essential hypertension (n=27) and with renoparenchymal hypertension (6 with chronic glomerular nephritis and 2 with diabetic nephropathy). The single oral dose of 10 mg nif edipine lowerd blood pressure promptly. In the patients with essential hypertension, the mean blood pressure lowered from 119.3±13.9 mmHg to 93.1±12.7 mmHg 30 minutes after administration (P<0.01). Glomerular filtration rate, renal blood flow, urinary volume and urinary sodium excretion increased markdely (by 33.4±46.8%, 36.6±52.3%, 89.7±96.2% and 68.3±89.5%, respectively). All these changes were significant (P<0.01) in paired t test. The decrease of tubular reabsorption ratio of sodium was thought to have something to do with natriuresis. However, in renoparenchymal hypertension, although blood pressure decreased almost the same degree as esential hypertension, glomerular filtration rate, renal blood flow and urinary volume decreased in some cases. This was thought to be bue to excessive decrease of renal perfusion pressure. Also 30 mg/day of oral nifedipine for 5 days induced some increase of 24 hours creatinine clearance in the papients with essential hypertension (n=8). These facts should be considered in the clinical use of calcium antagonists as an antihy pertensive drug.
- 社団法人 日本腎臓学会の論文
社団法人 日本腎臓学会 | 論文
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