ROLE OF TOLL-LIKE RECEPTOR 4 GENE IN THE EFFECT OF ANTI-CANCER AGENTS
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概要
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We examined the significance of TLR4 gene expression in anti-tumor immunity induced by OK-432 and OK-PSA that is the major effective molecule of OK-432. The results of the current study indicated that cytokine production and anti-cancer effects of OK-PSA are mediated by TLR4, and that IFN-γ induction in oral cancer patients given OK-432 peritumorally was correlated with expression of TLR4 and MD2, a co-factor for TLR4 signaling. In addition, Taxol and Taxotere, anti-cancer agents, activated NFκB, a transcription factor, mediated by TLR4 and MD2. These findings strongly suggest that TLR4/MD2 signaling is involved in anti-cancer immunity induced by bacteria-derived immunotherapeutic agents, and that some chemotherapeutic agents may activate NFκB mediated by TLR4/MD2 signaling.
- 日本頭頸部癌学会の論文
日本頭頸部癌学会 | 論文
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