Conformational Studies of Cyclo(Pro-Leu-Aib)2 by 1H Nuclear Magnetic Resonance Spectroscopy and Circular Dichroism.
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The synthesis and conformational analysis of cyclo(Pro-Leu-Aib)2 by means of NMR technique are reported. The cyclohexapeptide was synthesized in the classical high-dilution solution method. Its yield in the cyclization reaction from linear hexapeptide active ester was lower than that of the analogous cyclo(Pro-Leu-Gly)2 previously reported. Two sets of amide proton signals for Leu and Aib in NMR spectra and temperature coefficients indicated an asymmetric conformation which contains both cis and trans Aib-Pro bonds. Here Pro amino acids occupy the positions i+2 of β-turns. The CD spectrum gave two negative bands at 202 and 230 nm, which is considered to be the sum of type II′ (when Aib-Pro is trans) and type VI (when Aib-Pro is cis) β-turns.
- 公益社団法人 日本化学会の論文
公益社団法人 日本化学会 | 論文
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