A Divergent Synthesis of Lipid A and Its Chemically Stable Unnatural Analogues.
スポンサーリンク
概要
- 論文の詳細を見る
Lipid A and its two chemically stable analogues, wherein the glycosidic phosphoryl groups in lipid A is replaced with 2-(phosphonooxy)ethyl or carboxymethyl groups, have been synthesized by an improved and divergent route via a common allyl glycoside intermediate in which the 4-hydroxy group was protected as a benzyl ether. The total yields were more than 20% for 11 or 12 steps starting from allyl 4,6-O-benzylidene-2-deoxy-2-(trichloroethoxycarbonylamino)-<FONT SIZE="-2">D</FONT>-glucopyranoside. These synthetic chemically stable analogues induce interleukin-6 and tumor necrosis factor α in human peripheral whole blood cells with potencies comparable to those by natural-type synthetic lipid A. The Limulus activities of both analogues were found to be even stronger than the activity of the natural-type one.
- 公益社団法人 日本化学会の論文
公益社団法人 日本化学会 | 論文
- Spectrophotometric Studies on the Kinetics of Decomposition of Tetramethylmurexide in Acid Medium
- The Crystal Structures of Metal 8-Hydroxyquinolinate. I. Copper 8-Hydroxyquinolinate
- Hydrophile-Lipophile Balance Values for O/W Emulsions Stabilized by Nonionic Surfactants. I. Hydrophile-Lipophile Balance Values of Nonionic Surfactants Determined by Emulsification
- The Formation of Acetylenic Bond by the Elimination Reaction of Some Enol-esters. III. Formation of α, β-Acetylenic Carbonyl Compounds
- Ultraviolet Absorption Spectra of Lead Aldose-cysteinate