Detection of Urine Survivin in 40 Patients with Bladder Cancer

概要

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Purpose</B>: We investigated whether urine survivin, an inhibitor of the apoptosis protein, is useful for diagnosing bladder tumor. Method</B>: We measured urine survivin levels in 40 patients with bladder tumors and 9 healthy volunteers. Results</B>: The average urine survivin levels in the 40 patients and 9 healthy controls were not significantly different (3.802±8.669 and 1.127±1.529, respectively (p=0.3646) ). However, significantly high urine survivin levels were observed in 3 of the 40 patients, but not in healthy volunteers. Urine Cyfra 21-1 was not elevated (1.3 ng/ml) in one patient with a significantly elevated urine survivin level (33.54 ng/ml), while in two patients with elevated Cyfra (320 ng/ml and 240 ng/ml), the urine survivin level was not detectable. Conclusion: With improvements in the sensitivity of our Elisa system for urine survivin and combined use of urine Cyfra 21-1, it is possible that urine survivin will be a useful tumor marker in detecting both new-onset and recurrent bladder tumors.
日本医科大学医学会の論文