A Role for Fission Yeast Rab GTPase Ypt7p in Sporulation

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Ypt7p, a fission yeast (Schizosaccharomyces pombe) homologue of Rab7 GTPase, mediates fusion of endosomes to vacuoles and homotypic vacuole fusion. Here, we report that Ypt7p plays important roles in sporulation. Most ypt7Δ asci produced less than four spores, which were apparently immature and germinated at low frequency. Furthermore, ypt7Δ cells were defective in development of the forespore membranes. Vacuoles in sporulating cells were found to undergo extensive homotypic vacuole fusion to form a few large compartments occupying the entire cytoplasm of asci. This extensive vacuole fusion depended on Ypt7p.
日本細胞生物学会の論文