口腔癌に対する新しい併用療法の試み

概要

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The combined therapy of Bleomycin-iontophoresis, laser surgery, and radiation were applied to seven cases of oral carcinoma composed of five buccal lesions and two lesions of the floor of the mouth. In six cases, improvement was evident in both clinical and pathological findings. Large amounts of Bleomycin infiltrate easily into tissue by iontophoresis, so it may be remarkably effective to the localized lesion without causing side effects such as lung fibrosis, etc. The CO<SUB>2</SUB> laser is useful for surgical management of oral malignancy, because there is little bleeding and manipulation is easy. It seems that Bleomycin-Iontophoresis combined with laser surgery is effective for reduction of the infiltrated tumor. As this treatment produces only minor pain, bleeding, scaring or defect of the tissue, the oral function and architecture can be preserved. For older patients this procedure can be performed successfully as well as safely because side effects are minor and localized.
耳鼻と臨床会の論文