Effects of Nitrogen Oxides on Peroxidative Metabolism of Mouse Lung

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In order to examine the effect of nitrogen dioxide (NO2) or nitric oxide (NO) on peroxidative metabolism of lung, reduced glutathione (GSH) content and enzymatic activities of glutathione peroxidase (GPO), glutathione reductase (GR), and glucose-6-phosphate dehydragenase (G6PD) were studied in the lungs of mice exposed to NO2 or NO repeatedly (4 hours daily for 7 or 30 days). Exposure to 15 ppm NO2 for 7 days resulted in significant increase of GSH content. Exposure to 28 ppm NO2 for 7 days resulted in significant increase of not only GSH content but also the activities of GPO, GR, and G6PD. Exposure to 6 ppm NO2 for 30 days resulted in significant increase of the activities of GR and G6PD. The results show that NO2, as well as ozone (O3), stimulates the peroxidative metabolic pathway. The results also show that NO2 is less potent oxidant than O3 and that the mechanism of action of NO2 is different from that of O3. In repeated exposure to NO (12 or 21 ppm for 7 days, or 11 ppm for 30 days), there was no significant increase in GSH content or enzymatic activities. The effect of repeated exposure to NO2 or NO on acute toxicity of O3 was also studied.
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