Causal Relationship Between Benzo (a) pyrene and Lung Cancer

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In this experiment, Iron dusts, which were collected from the Cottrell instrument attached to an open hearth furnace, induced carcinomas of the lungs in Wistar-King rats when 7.5 mg were instilled intra-tracheally into the lungs once a week for 15 weeks. The incidence rate was 13.8 %, that is 4 tumor bearing rats out of 29 rats. Using the same method of intra-tracheal instillation, 1 mg of Benzo (a) pyrene (Bap) induced carcinomas of the lungs, the incidence rate was 22.0 %, that is 6 tumor bearing rats out of 27 rats. The suspension of 7.5 mg of the iron dusts with 1 mg of Bap induced carcinoma of the lungs and the incidence rate was 42.3 %, that is 11 tumor bearing rats out of 26 rats. In histopathological findings, almost all carcinomas were squamous cell carcinoma, 19 cases out of 21 cases, and on the contrary adenocarcinoma was present in only 2 cases out of 21 cases.<BR>In comparison among the incidence rates of 3 experimental groups, there was an additional association between the iron dusts and Bap for carcinogenicity to the lungs of rats.
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