Malignant Potential and Correlation between Prostaglandins, c-erbB-2 Oncoprotein Expression and Ploidy Pattern in Colon Cancer.
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The relation between prostaglandins, c-erbB-2 and DNA ploidy pattern was investigated in 55patients with colon cancer (11 with hepatic metastasis and 44 without hepatic metastasis) to assess malignant potential. The c-erbB-2 oncoprotein was immunohistochemically stained using a polyclonalantibody. Prostaglandin E<SUB>2</SUB> and D<SUB>2</SUB> were determined by the DCC method. DNA ploidy was determinedfrom formalin-fixed, paraffin-embedded tissue using an Epics-751 flow cytometer. The positive stainingrate of c-erbB-2 oncoprotein in the positive metastatic group was higher than that in the negative group.The DNA aneuploidy rate and mean of D.I. in the positive staining group were higher than those in thenegative staining group. There fore, it is suggested that c-erbB-2 might be an indicator for assessing themalignant potential of colon cancer. PGE<SUB>2</SUB> and D<SUB>2</SUB> tissue concentrations were lower in the positive metastatic group and/or positive oncoprotein cases. These findings suggest that PGs might play a role ininhibiting hepatic metastasis in colon cancer.
- 一般社団法人 日本消化器外科学会の論文
一般社団法人 日本消化器外科学会 | 論文
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