Studies of the Intraperitoneal Antibiotic Administration.
スポンサーリンク
概要
- 論文の詳細を見る
The value of intraperitoneal antibiotics to prevent postoperative infections was evaluated. The pharmacokinetics of 3 cephems (cefotiam, flomoxef, sulbactum/cefoperazone) were examined in patients undergoing gastroenterological surgery were examined. Patients received 1 g of cephem intravenously (DI) or intraperitoneally (IP) at the beginning of the operation. Thirty minutes after IP administration, the mean intraperitoneal fluid antibiotic level was 1000μg/ml, and it was 300μg/ml after 1 hour. Thirty minutes and 1 hour after administration each intraperitoneal fluid level in the IP group was significantly higher than that in the DI group. But 4 and 6 hours after administration the levels were the same. These results showed a high intraperitoneal fluid level was obtained in the IP group, but the amount of time exceeding the therapeutic intraperitoneal fluid level was not maintained compared with the DI group. The bactericidal activity of flomoxef (FMOX) against Escherichia coli sensitive to this antibiotics was dependent on the doses (400, 40, 4μg/ml). The production of endotoxin at a high antibiotic dose was less than that in controls which had no antibiotic administration. In saline where Escherichia coli even 400μg/ml of FMOX 30 had no bactericidal activity against Escherichia coli. No bactericidal activity against resistant strains such as Pseudomonas aeruginosa or methicillin resistant Staphylococcus aureus was obtained at 400μg/ml of FMOX. These studies lead to the speculation that the intraperitoneal fluid level and the amount of time exceeding the therapeutic level after PI administration has little efficacy in reducing the postoperative abdominal sepsis after peritonitis.
- 一般社団法人 日本消化器外科学会の論文
一般社団法人 日本消化器外科学会 | 論文
- A Case of Traumatic Injury of the Retrohepatic Inferior Vena Cava with Severe Liver Rupture.
- Cytoprotective Action of Co-enzyme Q10 and Ulinastatin on the Ischemic Damage of the Liver Following in Vivo Cold Infusion
- A Case Report of Lesser Omental Cyst.
- The Significance of Resection Range and Surgical Margin for Hepatocellular Carcinomas.
- Post transfusion hepatitis in heapatectomized patients.