A Case of Nonfunctioning Islet Cell Tumor Assessed Malignancy by Measuring the Nuclear DNA Content with a Flow Cytometer.
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A 60-year-old man without any clinical symptoms was found to have liver dysfunction by mass screening examination. Distal pancreatectomy was carried out under a preoperative diagnosis of pancreatic tail tumor. No clinical symptoms due to hormonal hypersecretion were recognized, but argyrophilic granules were demonstrated by Grimelius staining, and immunohistochemical staining showed positive immunoreactivity for chromogranin and neuronspecific enolase. Because ultrastructural examination revealed tumor cells with secretory granules, and the tumor showed vascular invasion, a diagnosis of nonfunctioning islet cell carcinoma was made. We measured the nuclear DNA content of the cancer cells with a flow cytometer. Nine of 11 samples showed aneuploidy (DI=1.36), and in other parts two different aneuploid lines (DI=1.36, 1.55) were disclosed in the same sample. The histologic diagnosis was supported by flow cytometric DNA analysis. However, the small fraction of S-phase cells suggests low proliferative activity of the tumor.
- 一般社団法人 日本消化器外科学会の論文
一般社団法人 日本消化器外科学会 | 論文
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