A Case Report of Hyperinsulinism
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概要
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Recently we experienced one patient of the islet cell tumor who was frequently attacked with a typical hypoglycemia. We measured the blood glucose level and found it was severely hypoglycemic. The fasting test was positive and a long duration of severe hypoglycemia was observed on the tolbutamide test.<BR>We also determined the serum insulin-like activity in this patient by the method with the hypophysectomized-adrenolectomized rats, that was 8.6 mu/ml and twice higher than that of normal.<BR>After tolbutamide was injected intravenously, the insulin-like activity elevated to 21.0 mu/ml. This prominent elevation may be considered to be specific for insuloma. From these data we diagnosed his disease as insuloma.<BR>On laparotomy we resected a tumor in size of the first finger from the head part of his pancreas. On the histological examination, it was found to be a benign islet cell adenoma in which the content of zinc and β-granules decreased.<BR>The amount of insulin in this tumor was 4.89u/g and it was twice higher than that of normal. The decrease of β-granules in the tumor does not coincide with the amount of insulin, but this may be due to the specificity of this kind of tumor.<BR>After the operation, the patient has never suffered from the seizure of hypoglycemia.
- 一般社団法人 日本糖尿病学会の論文
一般社団法人 日本糖尿病学会 | 論文
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