Effects of Low-dose Aspirin on Serum Concentrations of Soluble Adhesion Molecules in Patients with Type 2 Diabetes Mellitus.
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Aspirin is widely used by diabetic individuals as a prophylactic for atherosclerotic cardiovascular disease. Recently, the role of adhesion molecules on the development of atherosclerosis has been studied.However, the effects of aspirin on the expression of adhesion molecules <I>in vivo</I> has not been studied. In this study, 14 patients with type 2 diabetes and asymptomatic carotid atherosclerosis were given low-doses (81 mg/day) of aspirin for 12 weeks. HbA<SUB>1c</SUB>, lipids, blood pressure, and soluble adhesion molecules were measured before and after treatment. Fourteen patients of comparable age, sex, and carotid atherosclerosis status assigned to a control group. Throughout the study period, the treatment modalities for diabetes, hypertension, and dyslipidemia were not altered in either group. In both groups, HbA<SUB>1c</SUB>, lipids, and blood pressure did not change before and after treatment. Serum concentrations of soluble intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), and E-selectin did not change before and after treatment in the control group. In contrast, the serum concentrations of ICAM-1 decreased significantly after aspirin therapy (from 214.2ng/ml±16.1ng/m<I>l</I> to 193.0ng/m<I>l</I>±14.2ng/m<I>l</I>, p<0.05). Serum concentrations of VCAM-1 and E-selectin did not change significantly in aspirin-treated patients. Our results suggest that the anti-atherogenic effects of aspirin are explained, at least in part, by the reduced expression of ICAM-1.
- 一般社団法人 日本糖尿病学会の論文
一般社団法人 日本糖尿病学会 | 論文
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