A Case of Insulin-Dependent Diabetes Mellitus (IDDM) Following Interferon-.ALPHA. Therapy for Type C Chronic Hepatitis.
スポンサーリンク
概要
- 論文の詳細を見る
We report the case of a 51-year-old man who developed IDDM after interferon-α therapy (9 million U/day) for type C chronic active hepatitis.The patient's liver disorder was diagnosed as chronic active hepatitis with partial cirrhotic change by liver biopsy, and about 6 months after the institution of interferon-α(IFN-α) therapy he developed severe hyperglycemia.A diagnosis of IDDM was made since a large dose of insulin (68 U/day) was needed for glycemic control, the endogenous insulin secretion was severely impaired (urinary CPR: 12μg/day;Δ CPR<SUB>5</SUB>;0.3ng/m<I>l</I> during a 1mg glucagon load iv), and DR4 was detected in his HLA haplotype.<BR>IFN-α is thought to produce pancreatic B cell damage by enhancing the expression of major histocompatibility (MHC) antigen on the cell surface.A similar phenomenon may occur when the immune system is altered by HCV-indiuced liver disease.In addition, specific HLA haplotype is also thought to be a significant factor in this autoimmune response.We recommend that blood glucose levels and/or glucose tolerance be monitored during IFN therapy of type C chronic hepatitis.
- 一般社団法人 日本糖尿病学会の論文
一般社団法人 日本糖尿病学会 | 論文
- Hyperlipidemia and Analysis of the Use of Lipid-lowering Drugs in Non-insulin-dependent Diabetes Mellitus.
- Thyrotoxic Crisis in a Patient with Mitochondrial Diabetes Mellitus.
- Rapidly Progressive Nephropathy in a Young Patient with Mitochondrial Gene Mutation.
- An Autopsy Case of Ketoacidosis in Insulin Dependent Diabetes Mellitus Patient Complicated with Adult Respiratory Distress Syndrome, DIC and Leukopenia.
- Studies on Alcoholic Beverages in Relation to Body Weight for Mild Diabetics