Increased Arterio-Venous Shunt Rate in Diabetics with Neuropathy and Gangrene: The Quantitative Assessment of Autonomic Nerve Dysfunction by Whole Body Scintigraphy after Intraarterial Infusion of 99mTc-Microsphere Albumin through the Femoral Artery.:The
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This study evaluated whether the arterio-venous shunt rate (AVSR), calculated by the intraarterial infusion of <SUP>99m</SUP>Tc-microsphere albumin (MISA), can serve as a reliable index for the quantitative assessment of autonomic nerve disturbance in diabetics with various degrees of neuropathy. Ten diabetic patients with gangrene (group G) and 14 with (group N) and 14 without (group C) peripheral neuropathy were examined. <SUP>99m</SUP>Tc-MISA was injected percutaneously into both femoral arteries. The RI perfusion scans were performed, and radioactivity counts in the lungs and whole body were examined by scanning anteriorly and posteriorly, and AVSR were calculated.<BR>Results: 1) AVSR in group G (7.1±1.3%) and group N (3.9±0.3%) were significantly higher than that in group C (1.9±0.5%)(p<0.001). 2) There wasan inverse correlation between AVSR and the coefficient of variation of 100 R-R intervals on ECG (r=0.48 p<0.01).<BR>These results suggest that AVSR is a reliable index for quantitative assessment of autonomic nerve dysfunction in diabetics and that increased arterio-venous shunting blood flow is an important cause of diabetic gangrene.
- 一般社団法人 日本糖尿病学会の論文
一般社団法人 日本糖尿病学会 | 論文
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