Removal of Oxidized Cholesterol by Probucol in Diabetics with Hypercholesterolemia.
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概要
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Using gas chromatographic mass spectrometry, we identified cholesteryl-6 (2, 6-di-tertialy butylphenol-4)-thioether (CT) in the urine of diabetics with hypercholesterolemia who were being treated with oral glibenclamide, 2.5 mg, and probucol, 500 mg/day.<BR>Presumably probucol was hydrolyzed to form 4-mercapto-2, 6-di-tertialy-butylphenol (MBP), the MBP reacted with cholesterol-5 α, 6 α-epoxide, oxidized cholesterol, and CT was then formed as a result of dehydration and condensation reactions.<BR>Probucol is expected to be useful in preventing diabetic macroangiopathy and removing oxidized cholesterol from the plasma into the urine.
- 一般社団法人 日本糖尿病学会の論文
一般社団法人 日本糖尿病学会 | 論文
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