Comparison of Two Enzyme Immunoassays for IRI Using Mono-and Polyclonal Antibody: Influence of Antibody Specificity on IRI Values in Insulinoma Patients.
スポンサーリンク
概要
- 論文の詳細を見る
Enzyme immunoassay for insulin using a monoclonal antibody has been developed. The IRI value obtained by this new technique (dIRI) was reported to be similar to that obtained by the conventional method.In this study, we compared the dIRI values to those assayed using a polyclonal antibody (eIRI) in insulinoma patients. The dIRI values were about half of the eIRI values. The difference between IRI values in the two methods was significantly correlated to the proinsulin concentration in plasma. Considering the specificity of the antibodies, higher values of eIRI are likely due to the abundant proinsulin in insulinoma patients. Insulinoma indices such as the Fajan index (IRI/PG) and evaluation of IRI hyperresponse after glucagon administration are directly affected by IRI values. In diagnosing insulinoma, dIRI values should be judged carefully since hypersecretion of proinsulin is ignored in the dIRI assay.
- 一般社団法人 日本糖尿病学会の論文
一般社団法人 日本糖尿病学会 | 論文
- Hyperlipidemia and Analysis of the Use of Lipid-lowering Drugs in Non-insulin-dependent Diabetes Mellitus.
- Thyrotoxic Crisis in a Patient with Mitochondrial Diabetes Mellitus.
- Rapidly Progressive Nephropathy in a Young Patient with Mitochondrial Gene Mutation.
- An Autopsy Case of Ketoacidosis in Insulin Dependent Diabetes Mellitus Patient Complicated with Adult Respiratory Distress Syndrome, DIC and Leukopenia.
- Studies on Alcoholic Beverages in Relation to Body Weight for Mild Diabetics