The Content of Thrombospondin in STZ-Diabetic Rat Kidney and the Effect of High Glucose on its Production in Cultured Mesangial Cells.
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概要
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Thrombospondin (TSP), a multi-functional glycoprotein, has been identified in glomerular mesangial cells (M cell). The purpose of this study was to clarify whether TSP is associated with the pathogenesis of diabetic nephropathy. The TSP content of kidney cortex was higher, and the TSP content of kidney medulla was lower in diabetic rats than in control rats. It was also observed that TSP content and secretion were higher in glomeruli isolated from diabetic rats, and that TSP synthesis was enhanced by a high glucose concentration (33 mM) in cultured rat M cell at both logarithmic and confluent phases. Furthermore, fibronectin-mediated attachment and spreading of M cell were inhibited by additional coating with TSP. From these results, it is concluded that TSP-related metabolic abnormalities exist in the kidney tissue of STZ-diabetic rats. Increased TSP in glomeruli, especially in M cell, may play a role in the pathogenesis of diabetic nephropathy, presumably through its binding to many different macromolecules.
- 一般社団法人 日本糖尿病学会の論文
一般社団法人 日本糖尿病学会 | 論文
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