Risk Factors for Non-insulin Dependent Diabetes Mellitus in a Rural Japanese Population. Incidence and Risk Factors.:Incidence and Risk Factors
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There are no population-based prospective cohort studies which have estimated the incidence of and risk factors for non-insluin dependent diabetes (NIDDM) in a non-obese population in Japan. Thus, we have conducted a survey for NIDDM in Aito village, Shiga, Japan since 1980. The cohort consisted of 1338 subjects (566 males; 772 females) from 40-64 years of age, which covered 73% of eligible residents. The subjects were studied every 3 years and a 75 g oral glucose tolerance test (GTT) was performed in subjects with glucosuria at 1-h after 50 g oral glucose loading in non-fasting states. Subjects with glucosuria were followed by GTT every half year. Total observation was 7475 person-years and 56 newly diagnosed NIDDM were found during the 10 year follow-up period. Age-and sex-adjusted incidence was 8.2±1.2/1000 person-years.When subjects were divided to 3 groups by each sex's body mass index (BMI) tertile at entry, age-and sex-adjusted incidence in the obese (3rd tertile; BMI<23.14 kg/m<SUP>2</SUP> in males and BMI<23.78 kg/m<SUP>2</SUP> in females) was 3 times higher (p<0.01 by <I>x</I><SUP>2</SUP> test) than that in the lean (1 st tertile; BMI<20.9 kg/m<SUP>2</SUP> in males and BMI<21.36 kg/m<SUP>2</SUP> in females). However, in the obese subjects, sex-specific incidence in males decreased with aging, whereas the rate increased in females. When analyzed by Cox's proportional hazards model, higher BMI, aging, male gender, and higher blood pressure were independent risks for NIDDM. However, in males, higher BMI was the only significant risk for NIDDM. In conclusion, higher BMI was the most significant risk factor for NIDDM, even in a relatively non-obese population.Aging, male gender, and higher blood pressure were also important risk factors for developing NIDDM in Japan.
- 一般社団法人 日本糖尿病学会の論文
一般社団法人 日本糖尿病学会 | 論文
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