Effect of Pravastatin on Microalbuminuria in Patients with Non-Insulin-Dependent Diabetes Mellitus.

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We have studied the effect of pravastatin on microalbuminuria in hypercholesterolemic and normocholesterolemic patients with non insulin-dependent diabetes mellitus. A randomized design was used. Thirty three diabetic patients free of overt proteinuria were divided into two groups. One group was given pravastatin 10 mg/day and the other was treated as a control group. The ages of the patients, the duration of diabetes, glycemic control and the initial urinary albumin excretion rate were matched in each group. Urinary albumin concentration was measured by RIA and the albumin creatinine ratio (ACR) was calculated to observe the effect of pravastatin, on an out patient basis, for twelve months.<BR>In the group treated with pravastatin, ACR (mg/gCr) significantly (p<0.05) decreased from 129.3±86.1 to 69.4±62.9 (9 mo.) and to 78.8±87.0 (12 mo.). The control group showed no definite change in ACR during the twelve month period of observation. In conclusion, even short term treatment with pravastatin can reduce ACR in not only hypercholesterolemic but also normocholesterolemic patients with incipient diabetic nephropathy. In the pravastatin treated group, there was no significant correlation between ACR and other clinical findings. Furthermore, laboratory data before treatment weren't significantly different in the two group of patients, whose ACR decreased or were unchanged.
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