A Case of Advanced Age Onset Insulin-Dependent Diabetes Mellitus(IDDM).
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概要
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A 64-year-old female suffering from rheumatoid arthritis since age 53 and having a history of predonisolone treatment in earlier years was newly diagnosed as having diabetes mellitus at age 59. Her diabetes had been treated first with oral hypoglycemic agents, and later with insulin. At the age of 64, she was admitted to a near by hospital in a precoma state (plasma glucose 727 mg/dl) following upper respiratory infection, and was transferred to our hospital because of uncontrolled diabetes. During this hospitalization, urinary C-peptide levels were below the detectable limit of the assay. Islet cell antibody (ICA) and complement fixing ICA (CF-ICA) were positive, while islet cell surface antibody (ICSA) was negative. The former two autoantibodies remained positive throughout the observation period of 1 year. From the above results, this case seems to be compatible with slowly progressive IDDM. The Japanese literature reveals that, over age 60, newly diagnosed IDDM is rare in Japan. The clinical features of the 20 patients, including ours, suggest that these patients may be subdivided into two groups of acute onset and slowly progressive IDDM, with about half showing slowly progressive IDDM. Furthermore, our case provides further information on the clinical features and pathogenesis of advanced age onset IDDM.
- 一般社団法人 日本糖尿病学会の論文
一般社団法人 日本糖尿病学会 | 論文
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