Serum mannose in pregnant diabetics.
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概要
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A teratogenic property of mannose has been reported in animal studies. To elucidate the clinical significance of mannose in pregnancy we measured fasting serum mannose in sixtyeight pregnant diabetics in the first, the second and the third trimester using a gaschromatograph.<BR>In 120 normal pregnancies the fasting serum mannose levels were 0.64±0.28 mg/dl in the first trimester, and there was no significant change during the remainder of pregnancy.<BR>In the pregnant diabetics the fasting serum mannose levels were 0.84±0.45 mg/dl in the first, 0.75±0.41 mg/d/ in the second and 0.69±0.36 mg/d/ in the third trimester. These levels were higher than those in healthy pregnant women.<BR>There was a significant positive correlation between fasting serum mannose and glucose levels. Three out of ten women whose mannose levels were high in the first trimester had spontaneous abortions, however, we were unable to find any direct evidence of an effect of hypermannosemia on malformation of infants of diabetic mothers, because none of the infants born of the diabetic mothers examined had malformations.
- 一般社団法人 日本糖尿病学会の論文
一般社団法人 日本糖尿病学会 | 論文
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