Correlation between abnormal glucose metabolism and urinary catecholamine levels in pheochromocytoma.
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Forty-three cases of pheochromocytoma were investigated to reveal the relationship of abnormal glucose metabolism with urinary catecholamine levels. Diabetes mellitus (DM) was observed in 14 cases. A urinary excretion of adrenaline (A) of more than 300 μg/day, noradrenaline (NA) of more than 1, 000 μg/day, or in particular a compound value (A + NA/3) was a good indicator of the diabetic condition. The ratios of ΣIRI (the sum of individual serum insulin values in 75-g OGTT) to ΣPG (the sum of individual plasma glucose levels in 75-g OGTT) and ΔIRI (the IRI increment in the initial 30 minutes of OGTT) to ΔPG (the PG increment in the initial 30 minutes of OGTT) showed negative correlations most strongly with log (A + NA/9) and log A, respectively, (r=-0.700 and r=-0.636). These results indicate that the suppression of insulin secretion by increased plasma A is an important cause of abnormal glucose metabolism in pheochromocytoma. On the other hand, NA exerts a diabetogenic effect through decreased insulin sensitivity or enhanced glycogenolysis in the liver.
- 一般社団法人 日本糖尿病学会の論文
一般社団法人 日本糖尿病学会 | 論文
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