11-dehydro thromboxane B2 in diabetics.
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概要
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Measured levels of plasma thromboxane B<SUB>2</SUB> (TXB<SUB>2</SUB>) do not reflect endogenous thromboxane (TX) production precisely, because mechanical stimulation of platelets during blood sampling may cause TXB<SUB>2</SUB> production. il-Dehydro TXB<SUB>2</SUB> (11-DTX) which is one of the major metabolites of TXB<SUB>2</SUB> and is not converted from TXB<SUB>2</SUB> by blood cells or plasma, is considered suitable as a target for measurement of TX production <I>in vivo</I>. We measured, by radioimmunoassay, plasma TXB<SUB>2</SUB>, 11-DTX and the ability of platelets to produce TXB<SUB>2</SUB> during spontaneous clotting (TX production) in 46 diabetics and 31 normal controls.<BR>Plasma TXB<SUB>2</SUB> concentration and plasma 11-DTX concentration were higher in diabetics than in normal controls, but TX production did not differ between diabetics and normal controls. The plasma TXB<SUB>2</SUB>/11-DTX ratio had a tendency to be higher in diabetics than in normal controls. These results suggest that in diabetics, the high concentrations of plasma TXB<SUB>2</SUB> and 11-DTX are caused by high concentrations of circulating TXA<SUB>2</SUB> <I>in vivo</I>; and the high plasma TXB<SUB>2</SUB>/11-DTX ratio in diabetics may also indicate a tendency for increased synthesis of TXB<SUB>2</SUB> during blood sampling in diabetics.
- 一般社団法人 日本糖尿病学会の論文
一般社団法人 日本糖尿病学会 | 論文
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