A case of idiopathic hemochromatosis associated with allergy of human insulin.
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A 61 year-old woman, who had been treated for liver cirrhosis for five years, was admitted to our hospital because of insulin allergy and poor control of blood glucose. She had been treated with an oral hypoglycemia agent for a year after she was diagnosed as having diabetes mellitus. She had started human insulin therapy three months before admission, but shortly after that she had developed itchy skin wheals at the insulin-injected sites. On admission, intradermal injection of several types of human, porcine and bovine insulin give highly positive reactions. Her sera bound 95.2% of <SUP>125</SUP>I-human insulin added <I>in vitro</I>. The wheals, disappeared gradually with the combined injection of 0.06mg of dexamethasone with human insulin and her blood glucose was well controlled with 62U/day of insulin. As she was diagnosed as having idiopathic hemochromatosis by histological examination of a liver specimen and by other laboratory tests, repetitive phlebotomy and desferioxamine were administered. With these treatments, the insulin requirement decrease to 44U/day. These results show that insulin allergy occurs even with human insulin, and that in this patient the insulin requirement was affected by the idiopathic hemochromatosis itself as well as by the insulin allergy.
- 一般社団法人 日本糖尿病学会の論文
一般社団法人 日本糖尿病学会 | 論文
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