The effect of calcium antagonist(nicardipine hydrochloride) on insulin action.
スポンサーリンク
概要
- 論文の詳細を見る
The effect of nicardipine hydrochloride (NC), a calcium antagonist, on insulin action in peripheral tissues was examined in dogs. When NC was infused alone, it caused no significant changes in the IRI and IRG secretions. In the second experiment, an euglycemic glucose clamp test (EGCT) was performed. Sixty minutes after the beginning of EGCT, 1mg of NC was infused for 60 minutes, and the changes in the glucose disposal rate (DR) were observed. The DR was 14.5±0.31mg/kg/min before NC infusion, then it increased significantly to 17.5±0.73mg/kg/min during infusion of the NC, and significantly decreased to 13.5±0.58mg/kg/min after discontinuation of the NC infusion. The heart rate also increased with NC infusion, but remained increased even after the discontinuation of NC infusion. These findings indicate that NC increases the insulin-induced glucose utilization in the peripheral tissues.
- 一般社団法人 日本糖尿病学会の論文
一般社団法人 日本糖尿病学会 | 論文
- Hyperlipidemia and Analysis of the Use of Lipid-lowering Drugs in Non-insulin-dependent Diabetes Mellitus.
- Thyrotoxic Crisis in a Patient with Mitochondrial Diabetes Mellitus.
- Rapidly Progressive Nephropathy in a Young Patient with Mitochondrial Gene Mutation.
- An Autopsy Case of Ketoacidosis in Insulin Dependent Diabetes Mellitus Patient Complicated with Adult Respiratory Distress Syndrome, DIC and Leukopenia.
- Studies on Alcoholic Beverages in Relation to Body Weight for Mild Diabetics