Charactarization of insulin resistance assessed by the Euglycemic glucose clamp technique. Studies in patients with myotonic dystrophy.:Studies in Patients with Myotonic Dystrophy
スポンサーリンク
概要
- 論文の詳細を見る
To clarify the mechanism of insulin resistance in myotonic dystrophy, euglycemic glucose clamp and insulin binding study were performed on seven ambulatory patients with myotonic dystrophy and five age-matched control subjects. All patients showed normal glucose tolerance with enhance insulin secretion following oral glucose ingestion. During glucose clamps, insulin was infused at 40 and 200 mU/M <SUP>2</SUP>.BSA/min. The latter infusion rate, which resulted in steady state plasma insulin levels of approximately 1000 μ U/m<I>l</I>, was considered to give maximal glucose disposal. There was no significant difference in insulin clearance rates between patients and controls of either insulin infusion rate. In myotonic dystrophys, the maximal glucose disposal rate was decreased, suggesting a postreceptor defect. However, since muscle mass was decreased in the majority of patients, it seems likely that this may at least partially account for the decreased maximal glucose disposal rate expressed as mg/kg·Bw/min. Furthermore, from the ratio of glucose disposal obtained at 40 and 200 mU/M<SUP>2</SUP>·BSA/min it was suggested that the dose-response relationship of insulin-induced glucose disposal shifts rightward in myotonic dystrophy.<BR>Insulin binding was decreased in circulating erythrocytes and cultured fibroblasts from patients with myotonic dystrophy, due to a decrease in the affinity of the receptors.<BR>In summary, euglycemic glucose clamp study suggested decreased sensitivity and responsiveness to insulin in myotonic dystrophy. The decrease in insulin sensitivity may be accounted for by altered insulin binding related to a hereditary plasma membrane defect in myotonic dystrophy.
- 一般社団法人 日本糖尿病学会の論文
一般社団法人 日本糖尿病学会 | 論文
- Hyperlipidemia and Analysis of the Use of Lipid-lowering Drugs in Non-insulin-dependent Diabetes Mellitus.
- Thyrotoxic Crisis in a Patient with Mitochondrial Diabetes Mellitus.
- Rapidly Progressive Nephropathy in a Young Patient with Mitochondrial Gene Mutation.
- An Autopsy Case of Ketoacidosis in Insulin Dependent Diabetes Mellitus Patient Complicated with Adult Respiratory Distress Syndrome, DIC and Leukopenia.
- Studies on Alcoholic Beverages in Relation to Body Weight for Mild Diabetics